Thermo Fisher Scientific Phospho-PKA alpha (Ser339) Polyclonal Antibody
PKA alpha Ser339 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 검증됨. 1 mg/mL 농도의 액상 제품으로 -20°C 보관. 세포 신호전달 및 단백질 인산화 연구에 적합.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PKA alpha CAT around the phosphorylation site of Ser339 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903107 |
Target Information
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation, and behavior.
PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates into a PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers.
The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors.
PKAc-mediated activation of tonicity-dependent gene expression is cAMP-independent.
Humans express three types of PKAc subunit: PKAc alpha (present in most tissues), PKAc beta, and PKAc gamma (testes-specific).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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