Thermo Fisher Scientific Phospho-PKA alpha (Ser339) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Target Information

Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation, and behavior.
PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates into a PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers.
The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors.
PKAc-mediated activation of tonicity-dependent gene expression is cAMP-independent.
Humans express three types of PKAc subunit: PKAc alpha (present in most tissues), PKAc beta, and PKAc gamma (testes-specific).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.