Thermo Fisher Scientific Amphiregulin Monoclonal Antibody (AREG559), APC, eBioscience
인간 Amphiregulin(AR)을 인식하는 AREG559 단클론 항체로, APC 형광체가 결합된 제품입니다. Flow Cytometry 분석에 최적화되어 있으며, 조직 복원 및 면역 반응 연구에 유용합니다. 4°C에서 어둡게 보관하며 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.5 µg)/test
- Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AREG559 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2716941 |
Available Formats
Product Specific Information
Description:
The AREG559 monoclonal antibody reacts with human Amphiregulin (AR), a member of the Epidermal Growth Factor (EGF) family. AR is expressed as a transmembrane precursor protein and released by proteolytic cleavage. Soluble AR binds to the EGF receptor (EGFR), promoting growth of epithelial cells, fibroblasts, and keratinocytes.
In the immune system, AR functions in tissue repair, homeostasis, infection tolerance, and inflammation suppression. It is expressed in T cells, group 2 innate lymphoid cells, basophils, mast cells, eosinophils, and neutrophils under various conditions.
Applications Reported:
This AREG559 antibody is validated for use in flow cytometric analysis.
Applications Tested:
Pre-diluted and tested by flow cytometry on stimulated normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and the BestProtocols® “Protocol A: Two-step protocol for intracellular proteins.”
Recommended use: 5 µL (0.5 µg) per test (100 µL final volume). Cell number: 10⁵–10⁸ cells/test.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Target Information
Amphiregulin (AR) binds to EGFR with lower affinity than EGF. The mature secreted AR is an 84-amino acid glycosylated growth regulator derived from a 252-amino acid transmembrane precursor.
EGFR ligands include EGF, TGFα, AR, HB-EGF, cripto-1, epiregulin, and betacellulin, all containing a conserved EGF-like domain with six cysteine residues forming three disulfide-bonded loops.
AR protein is localized in the epithelium of the colon, stomach, pancreas, breast, and placenta, and is overexpressed in cancers of the breast, colon, stomach, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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