Thermo Fisher Scientific Pan SHANK Monoclonal Antibody (N23b/49), FITC
Pan SHANK 단백질을 인식하는 FITC 결합 단일클론 항체로, Western blot, IHC, ICC, IP 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 단백질 G로 정제된 액상형 제품입니다. 신경 시냅스 단백질 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000 | |
| Immunohistochemistry (IHC) | 1:1,000 | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Immunoprecipitation (IP) | Assay-dependent | |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N23b/49 |
| Immunogen | Fusion protein amino acids 84–309 of rat Shank2 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931893 |
Additional Formats Available
- Unconjugated (MA5-27633)
- APC (MA5-45438)
- PE (MA5-45441)
- PerCP (MA5-45440)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45439 was sufficient for detection of Shank1–4 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 160 kDa. Recognizes Shank1, Shank2, and Shank3.
Target Information
Shank proteins are a family of scaffold proteins that interact with various membrane and cytoplasmic proteins.
At postsynaptic sites of excitatory synapses, Shank proteins play key roles in signal transmission into postsynaptic neurons.
Studies indicate that Shank2 is expressed in developing retinal neurons and may be involved in neuronal differentiation.
Disruption of glutamate receptors at the Shank postsynaptic platform has been linked to postsynaptic density loss and synaptic dysfunction in Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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