Thermo Fisher Scientific Methyl-STAT5 (Arg31) Polyclonal Antibody
STAT5 Arg31 메틸화 특이성을 가진 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, ELISA, IP, Dot blot 등 다양한 분석에 적합. Human STAT5A 단백질에 대한 높은 특이성과 민감도를 제공하며, 연구용으로 안정적인 액상 형태로 공급.
- 카탈로그번호
- 600-401-GH4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Methyl-STAT5 (Arg31) Polyclonal Antibody
Thermo Fisher Scientific Methyl-STAT5 (Arg31) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| ELISA | 1:5,000 |
| Immunoprecipitation (IP) | 1:500 |
| Dot blot (DB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | STAT5A [Arg31-Methyl] affinity purified antibody prepared from rabbit serum immunized with a synthetic monomethylated peptide surrounding Arginine 31 of human STAT5A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 30% glycerol, 0.15M NaCl |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for STAT5 R31/Me1 and does not react with other STATs surrounding aa31. BLAST analysis suggests cross-reactivity with human, mouse, and rat STAT5. Cross-reactivity with STAT5 from other sources has not been determined.
Target Information
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis. The mouse counterpart induces BCL2L1/BCL-X(L) expression, suggesting anti-apoptotic function. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, though differential mRNA accumulation occurs in muscle and mammary tissues. STAT5 alpha plays critical roles in reproduction, lactation, immune function, and somatic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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