Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Amyloid Precursor Protein(APP)을 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, IP에 사용 가능. Human, Mouse, Rat 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. Alzheimer’s disease 연구에 적합.
- 카탈로그번호
- PA517829
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Immunoprecipitation (IP) | 2–5 µL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Thr668 of human APP695 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 197 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100 µg/mL BSA |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982330 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor involved in axonal transport of beta-secretase and presenilin 1. APP is essential for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing. Proteolytic cleavage by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques—one of the key histopathologic features of Alzheimer’s disease. Abnormal APP regulation and processing are also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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