Thermo Fisher Scientific Phospho-AMPK alpha-1,2 (Thr183, Thr172) Polyclonal Antibody
AMPK alpha-1,2의 Thr183 및 Thr172 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. -20°C에서 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 14 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Mouse, Pig, Plant, Rat, Sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptides corresponding to residues surrounding Thr183 of human AMPKα1 and Thr172 of AMPKα2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 83 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100 µg/mL BSA |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10983715 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK).
AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
AMPK functions as an energy-sensing enzyme that monitors cellular energy status.
Upon metabolic stress, AMPK is activated and phosphorylates key enzymes such as acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), regulating fatty acid and cholesterol biosynthesis.
Mouse studies suggest this subunit controls insulin sensitivity and maintains myocardial energy homeostasis during ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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