Thermo Fisher Scientific AIRE Polyclonal Antibody
AIRE 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot에 적합합니다. 인간과 생쥐 반응성이 확인되었으며, 농도는 0.5 mg/mL입니다. 합성 펩타이드 면역원으로 제작되었고, 연구용으로만 사용 가능합니다.
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- PA518640
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KAKPPKKPESSAEQ) corresponding to the internal amino acids of AIRE (aa 159–172) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981894 |
Product Specific Information
- This antibody is predicted to react with bovine, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
AIRE is a transcriptional regulator protein that binds DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression.
This nuclear protein (545 amino acids) contains an HSR domain, two PHD-type zinc fingers, and a SAND domain, and can form soluble high-molecular-weight complexes.
It interacts with transcriptional coactivators CBP and CREBBP.
Three isoforms of AIRE are reported, one of which is predicted to be a candidate for nuclear-mediated decay (NMD).
AIRE is involved in immune regulation and mediates E3 ubiquitin ligase activity.
Defects in AIRE cause the rare autosomal-recessive autoimmune disease known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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