Thermo Fisher Scientific FANCD2 Polyclonal Antibody, Biotin
FANCD2 단백질을 표적하는 Biotin 결합 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, Flow 등 다양한 응용에 적합. 인간 및 여러 종에서 반응. 고순도 Affinity chromatography 정제. 4°C 암소 보관.
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Thermo Fisher Scientific FANCD2 Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200–1:500 |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Avian, Dog, Human, Marsupial, Mouse, Non-human primate, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human FANCD2 fusion protein (N-terminal fragment) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152206 |
Product Specific Information
- In Western blot, this antibody should recognize a band at approximately 166 kDa (post-translationally modified form).
- Additional bands may be seen at lower molecular weights.
- In immunofluorescence, this antibody has been tested in human MMC and IR-treated MEF cells.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability and promotes accurate and efficient pairing of homologs during meiosis.
It is involved in the repair of DNA double-stranded breaks by homologous recombination and single-stranded annealing.
FANCD2 is required for targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress, and promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene result in Fanconi anemia complementation group D2, a disorder affecting all bone marrow elements and causing anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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