Thermo Fisher Scientific Phospho-Estrogen Receptor-a (Ser104) Polyclonal Antibody
Human estrogen receptor-alpha Ser104 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot 및 IHC에 적합하며, 고순도 Protein A 정제 및 1 mg/mL 농도의 액상 형태. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-Estrogen Receptor-a (Ser104) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunohistochemistry (IHC): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence including phosphorylation site of Serine 104 (S-V-S(p)-P-S) derived from human estrogen receptor and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes conformational change enabling dimerization and DNA binding to estrogen response elements (ERE). ERs regulate gene transcription through coactivator or corepressor recruitment.
Two forms exist: ER-alpha (ESR1) and ER-beta (ESR2). Alternative splicing produces at least four ER-alpha isoforms (66, 53, 47, 35 kDa).
Estrogen receptors are expressed widely across tissues, playing roles in sexual development, reproduction, bone metabolism, and are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 43070-100UL_Estrogen_Receptor_alpha_P03372-1_Rabbit.svg, 43070-100UL_Estrogen_Receptor_alpha_P03372-1_Rabbit_PDP.jpeg)
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