Thermo Fisher Scientific Phospho-Estrogen Receptor-a (Ser118) Polyclonal Antibody
인산화 에스트로겐 수용체 α(Ser118)에 특이적인 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 단백질 A로 정제된 액상 형태이며, -20°C에서 보관. 인간 시료에 반응하며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence including phosphorylation site of Serine 118 (Q-L-S(p)-P-F) derived from human estrogen receptor-alpha and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through recruitment of coactivator or corepressor proteins.
There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known to exist (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play roles in other tissues such as bone and are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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