Thermo Fisher Scientific P2X2 Receptor Polyclonal Antibody, Atto 594

Applications

• Immunohistochemistry (IHC): Assay-dependent

Product Specifications

Product Specific Information

Reconstitution: Add 50 µL of double distilled water (DDW), depending on the sample size.
This antibody is supplied as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
Avoid multiple freeze-thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

P2rx2 belongs to the ligand-gated ion channel family activated by extracellular ATP. Each receptor is a trimer composed of subunits (P2X1–7) sharing two transmembrane domains. P2rx2 mediates synaptic transmission between neurons and from neurons to smooth muscle.
It plays roles in excitatory postsynaptic responses, neuromuscular junction formation, hearing, taste perception, and peristalsis.
In the inner ear, P2rx2 regulates sound transduction, auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and potassium recycling.
Mutations in P2RX2 are associated with autosomal dominant deafness (DFNA41) and nonsyndromic hearing loss.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.