Thermo Fisher Scientific KCNIP3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Voltage-gated potassium (Kv) channels are essential components of potassium currents in the heart and central nervous system.
In the heart, Kv4 channels participate in the repolarization phase of the action potential, while in the brain they prevent reverse-propagation of action potentials.

KChIPs (Kv channel interacting proteins) are calcium-binding proteins associated with Kv4 channels that modulate their function.
There are three known KChIPs:

• KChIP1: expressed in the brain
• KChIP2: expressed in brain, heart, and lung (three isoforms: a, b, c)
• KChIP3: also known as calsenilin or DREAM (DRE-antagonist modulator), expressed in brain and testis

KChIP3 not only modulates Kv4 currents but also binds to the regulatory DRE and represses transcription from the early-response gene c-fos.
Thus, KChIP3 is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator.
KChIP3 is also associated with presenilins and implicated in beta-amyloid formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.