Thermo Fisher Scientific Aconitase 1 Polyclonal Antibody
Thermo Fisher의 Aconitase 1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 토끼 유래 다클론 항체입니다. Western blot과 IHC(P)에서 사용 가능하며, 세포 내 철 항상성 연구에 적합합니다. 단백질 A로 정제된 액상 제품으로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Aconitase 1/IRP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis.
Aconitase 1 exhibits aconitase enzymatic activity and is grouped within the aconitase enzyme family.
IREs are stem-loop structures located in the 5′ UTR of ferritin mRNA and the 3′ UTR of transferrin receptor mRNA.
Iron-induced binding to the IRE represses ferritin mRNA translation and stabilizes transferrin receptor mRNA, thereby regulating iron metabolism within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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