Thermo Fisher Scientific RRAD Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total RAD protein.

Target Information

The Ras-encoded family of proteins bind GDP and GTP with high affinity and exhibit low intrinsic GTPase activity, which increases significantly when interacting with cytosolic GTPase activating proteins (GAPs). Ras family members include H-Ras, K-Ras, N-Ras, M-Ras, R-Ras, ERas, Rheb, TC21, RASL11B, and Rad (Ras associated with diabetes) GTPase.

Rad GTPase is a GTP-binding protein similar to Ras but with unique properties. Unlike other small GTPases, Rad GTPase lacks typical prenylation motifs at its C terminus. It binds calmodulin, inhibits vascular lesion formation, has low intrinsic GTPase activity, and cannot be stimulated by known GAP molecules. Rad GTPase is expressed in skeletal muscle, cardiac muscle, and lung tissues, and is overexpressed in skeletal muscle tissue of individuals with type II diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.