Thermo Fisher Scientific Alpha A Crystallin Polyclonal Antibody
Alpha A Crystallin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫, 제브라피쉬 반응성. 고순도 Affinity 정제, -20°C 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:6,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–173 of human CRYAA (NP_000385.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.07 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914514 |
Product Specific Information
- Positive test controls: Mouse kidney, Mouse liver, Mouse heart
- Localization: Cytoplasm, Nucleus
Immunogen sequence:
MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSG ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH NERQDDHGYI SREFHRRYRL PSNVDQSALS CSLSADGMLT FCGPKIQTGL DATHAERAIP VSREEKPTSA PSS
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
- Alpha-crystallin: Largest class, composed of two primary gene products—alpha-A and alpha-B.
- Beta-crystallin: Composed of at least five different proteins.
- Gamma-crystallin: Monomeric, with at least five identified in bovine and rat lens.
Alpha-crystallin comprises about 40% of total lens protein composition. In addition to maintaining the refractive index, it functions as a molecular chaperone, preventing protein aggregation that may lead to cataract formation. Phosphorylation of alpha-crystallin is believed to occur in response to cellular stress, serving a structural control function and aiding in protein maintenance. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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