Thermo Fisher Scientific Bestrophin 1 Polyclonal Antibody
Thermo Fisher Scientific의 Bestrophin 1 Polyclonal Antibody는 인간 및 마우스 반응성을 가진 Rabbit IgG 기반 항체입니다. Western blot과 ELISA에 적합하며, 고순도 Affinity Chromatography로 정제되었습니다. 세포막 단백질 Bestrophin 1 검출에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 376–585 of human BEST1 (NP_004174.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914515 |
Product Specific Information
- Positive test controls: THP-1, BT-474, HeLa, Mouse heart, Mouse lung
- Localization: Basolateral cell membrane, Cell membrane, Multi-pass membrane protein
Immunogen sequence:
QPNQEDEEDA HAGIIGRFLG LQSHDHHPPR ANSRTKLLWP KRESLLHEGL PKNHKAAKQN VRGQEDNKAW KLKAVDAFKS APLYQRPGYY SAPQTPLSPT PMFFPLEPSA PSKLHSVTGI DTKDKSLKTV SSGAKKSFEL LSESDGALME HPEVSQVRRK TVEFNLTDMP EIPENHLKEP LEQSPTNIHT TLKDHMDPYW ALENRDEAHS
Target Information
The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant condition caused by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
This disease is often associated with mutations in the Bestrophin gene, which encodes a protein localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium, and missense mutations can abolish membrane current.
The human Bestrophin gene encodes a 585 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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