Thermo Fisher Scientific Bestrophin 1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls: THP-1, BT-474, HeLa, Mouse heart, Mouse lung
• Localization: Basolateral cell membrane, Cell membrane, Multi-pass membrane protein

Immunogen sequence:
QPNQEDEEDA HAGIIGRFLG LQSHDHHPPR ANSRTKLLWP KRESLLHEGL PKNHKAAKQN VRGQEDNKAW KLKAVDAFKS APLYQRPGYY SAPQTPLSPT PMFFPLEPSA PSKLHSVTGI DTKDKSLKTV SSGAKKSFEL LSESDGALME HPEVSQVRRK TVEFNLTDMP EIPENHLKEP LEQSPTNIHT TLKDHMDPYW ALENRDEAHS

Target Information

The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant condition caused by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
This disease is often associated with mutations in the Bestrophin gene, which encodes a protein localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium, and missense mutations can abolish membrane current.
The human Bestrophin gene encodes a 585 amino acid protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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