Thermo Fisher Scientific Alpha-synuclein Monoclonal Antibody (LB509)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse

Class

Monoclonal

Type

Antibody

Clone

LB509

Immunogen

Lewy Bodies purified from patients suffering dementia with Lewy Bodies if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:alpha Synuclein,uniProtId:P37840-1,ncbiNodeId:9606,antigenRange:1-140,antigenLength:140,antigenImageFileName:18-0215_alpha_Synuclein_P37840-1_House_mouse.svg,antigenImageFileNamePDP:18-0215_alpha_Synuclein_P37840-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS with 1% BSA

Contains

0.1% sodium azide

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2925241

Product Specific Information

Synucleins (α, β, and γ) are a family of cytoplasmic proteins found predominantly, and abundantly, in the brain with cellular distribution concentrated in presynaptic nerve terminals, primarily near vesicles. Synucleins are thought to be involved in neuronal plasticity, synaptic function, and neurodegenerative disease. α-Synuclein (~18 kDa) is abundant in Lewy Bodies in sporadic Parkinsons Disease (PD) and Dementia with Lewy Bodies (DLB). It has been reported that the NAC fragment from α-synuclein is a major component of amyloid plaques in Alzheimers Disease. LB509 reacts with α-synuclein but not SM-synuclein. Reactivity has not been observed with γ-synuclein. Positive tissue: Parkinson`s disease tissue.

Expected Staining Pattern: Cytoplasmic

Target Information

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinsons disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.