Thermo Fisher Scientific TNNI2 Monoclonal Antibody (OTI3A11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The TNNI2 gene encodes a fast-twitch skeletal muscle protein that is part of the troponin complex (troponin T, C, and I subunits). This complex, together with tropomyosin, regulates calcium-dependent striated muscle contraction.
Mouse studies indicate expression in vascular smooth muscle, suggesting a role in smooth muscle regulation.
Beyond muscle tissues, TNNI2 is found in corneal epithelium and cartilage (acting as an angiogenesis inhibitor), and in mammary gland tissue (as a co-activator of estrogen receptor-related receptor alpha).
It has tumor-suppressive roles in human ovarian carcinoma.
Mutations in this gene are associated with myopathy and distal arthrogryposis type 2B.
Alternative splicing results in multiple transcript variants.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.