Thermo Fisher Scientific Urokinase Polyclonal Antibody
Thermo Fisher Scientific의 Urokinase Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot과 ELISA에 적합합니다. 고순도의 rabbit IgG 폴리클로날 항체로, 액상 형태이며 -20°C에서 안정적으로 보관됩니다. 세포외기질 분해 및 암세포 이동 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–180 of human PLAU (NP_002649.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.57 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914370 |
Product Specific Information
Positive test controls include:
- HT-1080
- Mouse kidney
- Mouse brain
- Rat kidney
- Rat brain
Localization: Secreted
Immunogen sequence:
GSNELHQVPS NCDCLNGGTC VSNKYFSNIH WCNCPKKFGG QHCEIDKSKT CYEGNGHFYR GKASTDTMGR PCLPWNSATV LQQTYHAHRS DALQLGLGKH NYCRNPDNRR RPWCYVQVGL KPLVQECMVH DCADGKKPSS PPEELKFQCG QKTLRPRFKI I
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation.
A specific polymorphism in this gene may be associated with late-onset Alzheimer’s disease and decreased affinity for fibrin-binding.
This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen.
Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative (HMW-uPA).
HMW-uPA can be further processed into LMW-uPA, which remains proteolytically active but does not bind to the uPA receptor.
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-120798_Urokinase_P00749-1_Rabbit.svg, PA5-120798_Urokinase_P00749-1_Rabbit_PDP.jpeg)
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