Thermo Fisher Scientific PANK2 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 PANK2 폴리클로날 항체로, Western blot에 최적화되어 있습니다. Rabbit IgG 기반으로 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%) 제품입니다. CoA 생합성 관련 연구 및 PKAN 질환 연구에 적합합니다.
- 카탈로그번호
- PA575678
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PANK2 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human PANK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719406 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are also associated with hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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