Thermo Fisher Scientific Phospho-ETS1 (Ser251) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Target Information

ETS1 (also known as c-Ets-1, v-ets erythroblastosis virus E26 oncogene homolog 1 (avian), ETS-1, EWSR2, p54) is a 441 amino acid protein and a member of the DNA-binding ETS protein family.
It functions as a multifunctional transcription factor with:

• An N-terminal pointed domain
• A central transactivation domain
• Two auto-inhibitory domains flanking a conserved C-terminal ETS domain

ETS1 interacts with various cofactors including PEBP2alphaA and p300/CBP, mediating transactivation of genes such as Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
Activated by Ras/MAPK signaling, its expression is upregulated in resting T-cells.
ETS1 activity is modulated by AP-1, Sp-1, c-myb, MafB, and Sp100, which activates ETS1 in nuclear bodies.
It also interacts with EAP1/Daxx (repressing MMP1 and BCL2 transactivation), STAT6 (modulating Socs-1 expression induced by IL-4), and GATA3 (regulating Tax-1 dependent IL-5 expression).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.