Thermo Fisher Scientific Phospho-ETS1 (Ser251) Polyclonal Antibody
Rabbit에서 생산된 Phospho-ETS1 (Ser251) 폴리클로날 항체로, Western blot에 최적화되어 있습니다. Ser251 인산화 부위를 인식하며, Ras/MAPK 신호 경로 연구에 유용합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- 441107G
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of human ETS1 containing serine 251 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533576 |
Target Information
ETS1 (also known as c-Ets-1, v-ets erythroblastosis virus E26 oncogene homolog 1 (avian), ETS-1, EWSR2, p54) is a 441 amino acid protein and a member of the DNA-binding ETS protein family.
It functions as a multifunctional transcription factor with:
- An N-terminal pointed domain
- A central transactivation domain
- Two auto-inhibitory domains flanking a conserved C-terminal ETS domain
ETS1 interacts with various cofactors including PEBP2alphaA and p300/CBP, mediating transactivation of genes such as Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
Activated by Ras/MAPK signaling, its expression is upregulated in resting T-cells.
ETS1 activity is modulated by AP-1, Sp-1, c-myb, MafB, and Sp100, which activates ETS1 in nuclear bodies.
It also interacts with EAP1/Daxx (repressing MMP1 and BCL2 transactivation), STAT6 (modulating Socs-1 expression induced by IL-4), and GATA3 (regulating Tax-1 dependent IL-5 expression).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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