Thermo Fisher Scientific Human NDUFAF2 Synthetic Peptide
인간 Mimitin 단백질의 C-말단 14개 아미노산 서열에 대응하는 합성 펩타이드입니다. 항체 PA5-20831의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 PBS와 0.1% BSA에 보관되며, 연구용으로 적합합니다.
- 카탈로그번호
- PEP0945
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of Mimitin.
PEP-0945 can be used as a blocking peptide with polyclonal antibody PA5-20831.
Target Information
Mimitin is a small mitochondrial protein whose transcription is directly stimulated by c-Myc and is highly expressed in approximately 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference showed no effect in certain cancer cell lines such as human cervical carcinoma or hepatocarcinoma, but caused decreased proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC. This suggests Mimitin may play a specific role in these cell types.
Mimitin expression is regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It interacts with the microtubular protein MAP1S and can affect caspase-3 and -7 activities during apoptosis. Other studies indicate Mimitin may act as a molecular chaperone for mitochondrial complex I assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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