Thermo Fisher Scientific Human FRMPD1 Synthetic Peptide
FRMPD1 단백질의 C-말단 15개 아미노산 서열로 구성된 합성 펩타이드. FRMPD1 항체(PA5-20832)와 함께 차단 실험에 사용 가능. 인간 유래 단백질 반응성. 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of FRMPD1.
PEP-0946 can be used as a blocking peptide with polyclonal antibody PA5-20832.
Target Information
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, ezrin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occludens-1) domain.
FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gαi.
FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by approximately 50% and enhanced the inhibition of forskolin-induced increases in cAMP.
Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gαi3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Gαi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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