Thermo Fisher Scientific PRDX5 Recombinant Rabbit Monoclonal Antibody (002)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal production clones.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to large rabbit immune repertoire

This antibody has specificity for Human Peroxiredoxin 5 (PRDX5).

Target Information

Peroxiredoxin (Prx) is a peroxidase family associated with cell proliferation, differentiation, and apoptosis. Mammalian Prx proteins (approximately 50 isoforms) contain active site cysteine residues and exhibit thiol-specific antioxidant activity.

Mammalian Prx members are categorized into:

• Typical 2-Cys Prx
• Atypical 2-Cys Prx
• 1-Cys Prx

Except for Prx VI (1-Cys subgroup), other 2-Cys Prx isotypes possess thioredoxin-dependent peroxidase (TPx) activity using thioredoxin, thioredoxin reductase, and NADPH as reducing systems.

Mammalian Prxs (20–30 kDa) vary in subcellular localization:

• Prx I, II, VI: cytosol
• Prx III: mitochondria
• Prx IV: ER and secretion
• Prx V: peroxisome, mitochondria, and cytosol

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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