Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody
CaMKII alpha 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC 등 다양한 응용에 사용 가능. 인간에 반응하며, 마우스와 랫에서도 예측 반응. 고순도 정제 및 안정한 저장 조건 제공. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | View 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Immunoprecipitation (IP) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between amino acids 344–371 from the C-terminal region of human CAMK2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion chromatography, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2070314 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates various cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal organization, and calcium homeostasis.
Autophosphorylation at threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling calmodulin-independent activity.
CaMKII plays critical roles in dendritic spine and synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle.
In neurons, it contributes structurally to actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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