Thermo Fisher Scientific CaV1.2 (CACNA1C) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size
• Ships as lyophilized powder at room temperature
• Store at -20°C upon arrival
• Reconstituted solution stable at 4°C for up to 1 week
• For long-term storage, aliquot and store at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

CACNA1C encodes the alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate calcium ion influx into cells upon membrane depolarization.
The alpha-1 subunit forms the ion-conducting pore and consists of 24 transmembrane segments.
Calcium channels are composed of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Multiple isoforms exist due to alternative splicing or distinct genes.
The CACNA1C protein binds to and is inhibited by dihydropyridine.
Alternative splicing results in various transcript variants encoding different proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.