Thermo Fisher Scientific PHLPP2 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 0.1–0.3 µg/mL
• Publications: Not available

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II, and Ser-657 of PRKCA.
Akt regulates the balance between cell survival and apoptosis through transcription factors that control pro- and antiapoptotic genes.
Dephosphorylation of Ser-473 of Akt triggers apoptosis and decreases cell proliferation. Also controls phosphorylation of AKT3.
Dephosphorylates STK4 on Thr-387 leading to STK4 activation and apoptosis (PubMed:20513427).
Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499).
Inhibits cancer cell proliferation and may act as a tumor suppressor.
Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation.
Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). [UniProt]

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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