Thermo Fisher Scientific PHLPP2 Polyclonal Antibody
PHLPP2 단백질을 표적으로 하는 Thermo Fisher Scientific의 산양 유래 폴리클로날 항체. Western blot에서 0.1–0.3 µg/mL로 검증됨. 세포 생존 및 아폽토시스 조절 연구에 적합하며, 액상 형태로 -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- PA518758
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 0.1–0.3 µg/mL
- Publications: Not available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (PHEEDRTEPPEEFD) corresponding to the C-terminus amino acids of PHLPPL (aa 1307–1321) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11003216 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II, and Ser-657 of PRKCA.
Akt regulates the balance between cell survival and apoptosis through transcription factors that control pro- and antiapoptotic genes.
Dephosphorylation of Ser-473 of Akt triggers apoptosis and decreases cell proliferation. Also controls phosphorylation of AKT3.
Dephosphorylates STK4 on Thr-387 leading to STK4 activation and apoptosis (PubMed:20513427).
Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499).
Inhibits cancer cell proliferation and may act as a tumor suppressor.
Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation.
Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). [UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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