Thermo Fisher Scientific CD20 Monoclonal Antibody (13.6E12)
인간 CD20 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, IHC(P) 및 유세포분석(Flow)에 사용 가능. 비결합형 액상 형태이며 Protein A로 정제됨. B 세포 표면 CD20 검출 및 연구용에 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 2–10 µg/mL
Flow Cytometry [Flow]
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13.6E12 |
| Immunogen | A recombinant protein of human CD20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Thymus
- Cellular location: Membrane
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells. It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. CD20 is associated with lipid rafts, and its surface expression remains stable following antibody treatment, making it a useful target for antibody-mediated B-cell depletion. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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