Thermo Fisher Scientific PRDX4 Polyclonal Antibody
PRDX4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 시료에 특이적이며 다른 Prx 이소폼과 교차 반응하지 않습니다. Western blot 및 면역세포화학(ICC/IF)에 적합하며, 연구용으로만 사용 가능합니다.
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- PA3753
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | View 3 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified human recombinant Peroxiredoxin 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2168495 |
Product Specific Information
PA3-753 detects Peroxiredoxin 4 (Prx 4) protein in human samples.
This antibody is specific for Prx 4 and shows no cross-reactivity with other Prx isoforms.
It has been successfully used in Western blot and immunocytochemistry procedures.
By Western blot, this antibody detects ~23 kDa and ~20 kDa proteins representing pro-Prx 4 and mature Prx 4, respectively, in human PC3 cell lysate.
The antigen used is purified human recombinant Prx 4 from K562 cells.
Target Information
Peroxiredoxin (Prx) is a peroxidase family associated with cell proliferation, differentiation, and apoptosis.
Mammalian Prx proteins (approximately 50) share sequence homology and thiol-specific antioxidant activity, distributed across all kingdoms of life.
Mammalian Prx members are grouped into typical 2-Cys, atypical 2-Cys, and 1-Cys Prx types.
Except for Prx VI (1-Cys subgroup), the other five 2-Cys Prx isotypes have thioredoxin-dependent peroxidase (TPx) activity using thioredoxin, thioredoxin reductase, and NADPH as a reducing system.
Mammalian Prxs are 20–30 kDa in size and vary in subcellular localization:
- Prx I, II, VI: cytosol
- Prx III: mitochondria
- Prx IV: endoplasmic reticulum and secretion
- Prx V: peroxisome, mitochondria, and cytosol
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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