Thermo Fisher Scientific GP6 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Samples: Jurkat, human plasma
• Cellular Location: Cell membrane, Single-pass membrane protein

Immunogen sequence:
QSGPLPKPSL QALPSSLVPL EKPVTLRCQG PPGVDLYRLE KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS DQLELVATGV FAKPSLSAQP GPAVSSGGDV TLQCQTRYGF DQFALYKEGD PAPYKNPERW YRASFPIITV TAAHSGTYRC YSFSSRDPYL WSAPSDPLEL VVTGTSVTPS RLPTEPPSPV AEFSEATAEL TVSFTNEVFT TETSRSITAS PKESDSPAGP ARQYYTK

Target Information

Glycoprotein VI (GP6) is a 58-kDa platelet membrane glycoprotein crucial for collagen-induced platelet activation and aggregation. Upon vascular injury, exposure of the subendothelial matrix to blood flow leads to platelet deposition. Collagen fibers (types I, III, and VI) are the main thrombogenic components. Platelet interaction with collagen occurs in two steps:

1. Initial adhesion to collagen
2. Activation leading to secretion, recruitment, and aggregation

This process forms a platelet plug that limits blood loss. However, collagen exposure after atherosclerotic plaque rupture can trigger thrombus formation associated with myocardial infarction or stroke.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.