Thermo Fisher Scientific PFTK1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 312-451 of human CDK14 (NP_0365271) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PFTK1,uniProtId:O94921-1,ncbiNodeId:9606,antigenRange:312-451,antigenLength:469,antigenImageFileName:PA5-90166_PFTK1_O94921-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90166_PFTK1_O94921-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.52 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805943

Product Specific Information

Immunogen sequence: AAFPGMKDIQ DQLERIFLVL GTPNEDTWPG VHSLPHFKPE RFTLYSSKNL RQAWNKLSYV NHAEDLASKL LQCSPKNRLS AQAALSHEYF SDLPPRLWEL TDMSSIFTVP NVRLQPEAGE SMRAFGKNNS YGKSLSNSKH; Positive Samples: Mouse testis; Cellular Location: Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein

Target Information

CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family which is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with esophageal squamous cell carcinoma.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.