Thermo Fisher Scientific JAK3 Monoclonal Antibody (OTI1B4), TrueMAB
Human JAK3 단백질(aa 811-1124)에 특이적인 Mouse Monoclonal Antibody (Clone OTI1B4). Western Blot에 최적화되어 있으며, Lyophilized 형태로 제공. PBS, 8% trehalose buffer에 보존되고, 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 811–1124 of human JAK3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family.
JAK3 is mainly expressed in immune cells and mediates signaling through interleukin receptors. Upon cytokine stimulation (e.g., interferons, interleukins), JAKs are activated via phosphorylation at adjacent tyrosine residues, leading to activation and nuclear translocation of STAT proteins. These STAT dimers regulate transcription of multiple genes, including interferon-stimulated genes.
JAK2 is essential for IFN-γ receptor complex initiation, JAK1 acts as an amplifier, and JAK3 may substitute for JAK2 or Tyk2 under specific receptor configurations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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