Thermo Fisher Scientific MLNR Polyclonal Antibody
MLNR 단백질을 인식하는 토끼 폴리클로날 항체로, 인간 및 영장류 시료에 반응합니다. IHC(P)에서 1 µg/mL로 사용되며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from internal region of human MLNR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551305 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey (100%), Gibbon (95%), Bovine (89%), Marmoset (84%).
Target Information
Motilin is a widely conserved 22 amino acid peptide hormone secreted from enterochromaffin cells of the gastrointestinal tract. Within the intestines, motilin potentiates intestinal motility by inducing contractions of the duodenum and through binding to surface receptors, designated GPR38 (G-protein coupled receptor 38).
These motilin receptors are predominantly expressed in the stomach, thyroid, and bone marrow, and are related to other G-protein coupled receptors located in the pituitary and hypothalamus, which mediate the signaling for growth hormone secretagogues.
The gene encoding GPR38 is alternately spliced at the carboxy terminus to generate two related proteins, GPR38-A and GPR38-B. Sequence comparisons indicate that GPR38-A contains seven transmembrane domains while GPR38-B is predicted to contain only five. Consistent with other G-protein coupled receptors, GPR38 activates phospholipase C signal transduction pathways and induces intracellular calcium mobilization after binding of motilin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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