Thermo Fisher Scientific MLNR Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 1 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey (100%), Gibbon (95%), Bovine (89%), Marmoset (84%).

Target Information

Motilin is a widely conserved 22 amino acid peptide hormone secreted from enterochromaffin cells of the gastrointestinal tract. Within the intestines, motilin potentiates intestinal motility by inducing contractions of the duodenum and through binding to surface receptors, designated GPR38 (G-protein coupled receptor 38).
These motilin receptors are predominantly expressed in the stomach, thyroid, and bone marrow, and are related to other G-protein coupled receptors located in the pituitary and hypothalamus, which mediate the signaling for growth hormone secretagogues.
The gene encoding GPR38 is alternately spliced at the carboxy terminus to generate two related proteins, GPR38-A and GPR38-B. Sequence comparisons indicate that GPR38-A contains seven transmembrane domains while GPR38-B is predicted to contain only five. Consistent with other G-protein coupled receptors, GPR38 activates phospholipase C signal transduction pathways and induces intracellular calcium mobilization after binding of motilin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.