Thermo Fisher Scientific TPM2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000

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Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full length human Tropomyosin 2 Recombinant protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TPM2,uniProtId:P07951-1,ncbiNodeId:9606,antigenRange:1-284|1-234,antigenLength:284,antigenImageFileName:PA5-22012_TPM2_P07951-1_Rabbit.svg,antigenImageFileNamePDP:PA5-22012_TPM2_P07951-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.66 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_11156208

Product Specific Information

Recommended positive controls: HeLa.

Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (84%), Pig (98%), Rabbit (99%), Bovine (92%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TPM2 (tropomyosin 2) is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers. TPM2 binds to actin filaments in muscle and non-muscle cells. Plays a central role in association with the troponin complex in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Mutations in this gene can cause nemaline myopathy 4, arthrogryposis dital 1A/2B, and cap myopathy 2.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.