Thermo Fisher Scientific CD2AP Polyclonal Antibody
CD2AP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적. 세포골격 및 막 단백질 상호작용 연구에 적합.
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Thermo Fisher Scientific CD2AP Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD2AP. Recombinant protein control fragment (Product #RP-101068). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639538 |
Product Specific Information
Immunogen sequence:
VDFDSLTVRT SKETDVVNFD DIASSENLLH LTANRPKMPG RRLPGRFNGG HSPTHSPEKI LKLPKEEDSA NLKPSELKKD TCYSPKPSVY LSTPSSASKA NTTAFLTPLE IKAKVETDDV KKNSLDELRA QIIELLCIVE ALKKDHGKEL
Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 82%
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and various cell membrane proteins through multiple actin-binding sites, SH3 domains, and a proline-rich region. It localizes to membrane ruffles, lipid rafts, and leading cell edges. CD2AP is involved in dynamic actin remodeling and membrane trafficking during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene may contribute to glomerular disease susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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