Thermo Fisher Scientific CD25 Monoclonal Antibody (CD25-4E3), FITC, eBioscience
인간 및 비인간 영장류 CD25 인식 단클론 항체로, FITC 형광 표지되어 Flow Cytometry 분석에 최적화됨. IL-2 수용체 α체인 검출용으로 사용되며, 고품질 정제 및 안정적 저장 조건 제공. 연구용 전용 제품.
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Thermo Fisher Scientific CD25 Monoclonal Antibody (CD25-4E3), FITC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.25 µg)/test
Publications: View 12 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD25-4E3 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572447 |
Additional Formats
- APC
- APC-eFluor 780
- Brilliant Violet 605
- eFluor 450
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 645
- Super Bright 702
- Request custom conjugation
Product Specific Information
This CD25-4E3 monoclonal antibody reacts with human CD25, also known as the low-affinity interleukin (IL)-2 receptor alpha.
CD25 is expressed on activated T cells (including regulatory T cells), B cells, and macrophages. It forms the high-affinity IL-2 receptor complex with CD122 (IL-2Rβ) and CD132 (γ chain), mediating lymphocyte proliferation and survival.
CD25 serves as a marker for Hodgkin’s disease and is linked to autoimmune diseases such as Type I diabetes.
- Cross-reactive to rhesus monkey
- Reported for use in flow cytometric analysis
- Pre-titrated and tested on normal human peripheral blood cells
- Recommended usage: 5 µL (0.25 µg) per test (100 µL final volume)
- Excitation: 488 nm; Emission: 520 nm; Laser: Blue
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD25 (IL2RA) encodes the IL-2 receptor α chain, a cytokine receptor involved in T and B lymphocyte proliferation.
The IL2 receptor complex (IL2RA, IL2RB, IL2RG) provides high-affinity binding for IL-2.
Homodimeric IL2RA chains yield low-affinity receptors, while IL2RB homodimers produce medium-affinity receptors.
IL2 expression in mature thymocytes is monoallelic, ensuring precise gene regulation.
IL2 functions as a growth and differentiation factor, promoting B-cell proliferation, NK cell activity, and inhibiting granulocyte macrophage colony formation.
Mutations in IL2RA are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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