Thermo Fisher Scientific PDX1 Monoclonal Antibody (OTI3H3), TrueMAB

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

The PDX1 protein is a transcriptional activator regulating genes such as insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2.
This nuclear protein is critical for pancreatic development and glucose-dependent regulation of insulin gene expression.
Defects in the PDX1 gene can cause pancreatic agenesis, leading to early-onset insulin-dependent diabetes mellitus (NIDDM) and maturity onset diabetes of the young type 4 (MODY4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.