Thermo Fisher Scientific PTCH Polyclonal Antibody
Human 및 Mouse에 반응하는 PTCH 폴리클로날 항체로, IHC(P) 및 ICC/IF에 사용 가능. C-말단 합성 펩타이드로부터 유래된 항원 사용. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 8 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ELQDVECEERPR) corresponding to the C-terminus amino acids of PTCH1 (aa 1431–1442). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10979628 |
Product Specific Information
- Predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA with antibody detection limit dilution of 1:16,000.
Target Information
This gene encodes a member of the patched gene family. The encoded protein acts as the receptor for sonic hedgehog, a secreted molecule involved in embryonic structure formation and tumorigenesis, as well as desert hedgehog and indian hedgehog proteins.
This gene functions as a tumor suppressor. Mutations have been linked to basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly.
Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full-length sequences and biological validity remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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