Thermo Fisher Scientific CTRP1 Polyclonal Antibody

Applications

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

• Suggested positive control: MDA-MB-361 cell lysate
• PA5-20145 can be used with blocking peptide PEP-0265

Target Information

Adipose tissue plays a major role in regulating physiological and pathological processes such as metabolism and immunity by producing and secreting bioactive molecules called adipokines.
A highly conserved family of adipokines includes adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1–7.
Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, CTRPs are expressed in a wide variety of tissues and are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism.
Crystal structure analysis of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting a common ancestral innate immunity gene.
In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are expressed at substantially higher levels in adipose tissues compared to normal mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.