Thermo Fisher Scientific SMAD1/SMAD9 Polyclonal Antibody
SMAD1/SMAD9 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 유래 합성 펩타이드로부터 제작되었으며, 내인성 Smad1/9 단백질을 검출합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMAD1 (Accession Q15797), corresponding to amino acid residues I436–S465. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817648 |
Product Specific Information
This antibody detects endogenous levels of total Smad1/9.
Target Information
The protein encoded by this gene belongs to the SMAD family, homologous to the Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma genes.
SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
SMAD1/9 mediates bone morphogenetic protein (BMP) signaling, involved in cell growth, apoptosis, morphogenesis, development, and immune responses.
Upon BMP ligand binding, SMAD1/9 is phosphorylated by BMP receptor kinase and forms a complex with SMAD4 to regulate transcription.
It is also a target for SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2), leading to ubiquitination and proteasome-mediated degradation.
Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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