Thermo Fisher Scientific HLA-E Polyclonal Antibody
HLA-E 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Human, Mouse, Rat 반응성을 가지며, Affinity chromatography로 정제된 고품질 항체입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5106269
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HLA-E (Accession P13747), corresponding to amino acid residues H218–V268 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853946 |
Product Specific Information
Antibody detects endogenous levels of total HLA-E.
Target Information
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane.
HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons.
- Exon 1: leader peptide
- Exons 2–3: alpha1 and alpha2 domains (peptide binding)
- Exon 4: alpha3 domain
- Exon 5: transmembrane region
- Exons 6–7: cytoplasmic tail
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-106269_HLA-E_P13747-1_Rabbit_PDP.jpeg)
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