Thermo Fisher Scientific TAS2R38 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:1,000

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TAS2R38.

Target Information

Receptor that may play a role in the perception of bitterness and is gustducin-linked.
May play a role in sensing the chemical composition of the gastrointestinal content.
The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting); also called thiourea tasting.
The ability to taste the substance PTC and related substances is genetically controlled.
Genetic studies have demonstrated complex inheritance for this trait.
For some people (and some chimpanzees also), PTC tastes very bitter; for others, it is tasteless.
Substantial variation in taste sensitivity exists in humans.
Five haplotypes arising from three coding SNPs in the TAS2R38 gene are associated with distinct phenotypes of PTC taste sensitivity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.