Thermo Fisher Scientific Tankyrase 1 Polyclonal Antibody
Tankyrase 1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot과 IHC에 사용 가능하며, Wnt 신호전달 및 텔로미어 조절 연구에 적합합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 보관하십시오.
- 카탈로그번호
- OST00399W-100UL
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acids 1270–1320 of mouse TNKS1 conjugated to blue carrier protein. The peptide is homologous in human. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide antigen is homologous in human.
- Specificity: TNKS1.
Target Information
Poly-ADP-ribosyltransferase involved in processes such as Wnt signaling, telomere length regulation, and vesicle trafficking.
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, leading to their ubiquitination and degradation.
Also mediates PARsylation of BLZF1, CASC3, TERF1, HEPACAM2/MIKI, and NUMA1, contributing to telomere regulation, centrosome maturation, and spindle pole assembly.
May regulate vesicle trafficking and modulate SLC2A4/GLUT4-vesicle distribution.
Stimulates 26S proteasome activity.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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