Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: Tau, isoforms 1, 5, 8.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker protein between both.
Axonal polarity is determined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome. Short isoforms provide cytoskeletal plasticity, whereas longer isoforms contribute to stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs Tau’s microtubule-binding function, leading to microtubule destabilization and neuronal degeneration.

Tau phosphorylation is mediated by various kinases including GSK-3β, PKA, CDK5, and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions associated with Alzheimer’s, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.