Thermo Fisher Scientific Human DR5 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 20 amino acids near the carboxy terminus of human DR5.
PEP-0021 can be used as a blocking peptide with polyclonal antibody PA5-19895.

Target Information

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain-containing receptor for TRAIL, which mediates TRAIL-induced apoptosis.
DR5 is a member of the TNF-receptor superfamily and contains an intracellular death domain. It can be activated by tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL/APO-2L) and transduces an apoptosis signal.

Studies with FADD-deficient mice suggested that FADD, a death domain-containing adaptor protein, is required for the apoptosis mediated by DR5.
Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B.

DR5 is expressed in various cell types, particularly at high levels in lymphocytes and spleen.
Diseases associated with DR5 dysfunction include squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.