Thermo Fisher Scientific Mouse ICAD Synthetic Peptide
마우스 ICAD 단백질의 N-말단 20개 아미노산 서열에 해당하는 합성 펩타이드. PA5-19889 항체와 함께 차단 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며 PBS 완충액에 0.1% BSA 포함. 연구용으로만 사용.
- 카탈로그번호
- PEP0017
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acid residues at the amino terminus of mouse ICAD.
PEP-0017 can be used as a blocking peptide with polyclonal antibody PA5-19889.
Target Information
ICAD is the inhibitor of caspase-3-activated DNase, which controls nuclear apoptosis.
It has two isoforms:
- ICAD-L/DFF45 (45 kDa): functional isoform
- ICAD-S/DFF35 (35 kDa): non-functional isoform
Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L is functional. ICAD is cleaved to allow caspase-activated DNase (CAD) to execute apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with ICAD. Activation occurs through caspase-3-mediated cleavage of ICAD at residues 117 and 224, producing three fragments released from CAD.
Beyond its DNase inhibitory role, ICAD acts as a CAD-specific folding chaperone. Recent studies suggest ICAD may be a potential target for restoring normal apoptotic signaling in colon and brain cancer cells. Two alternatively spliced transcript variants encoding distinct isoforms have been identified for the ICAD gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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