Thermo Fisher Scientific UGT1A6 Polyclonal Antibody
Rabbit polyclonal antibody against UGT1A6, validated for WB and IHC-P. Reacts with human and mouse. Antigen affinity purified, liquid form. Suitable for studying glucuronidation pathway enzymes. For research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | — |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 8–227 of UGT1A6 (Uniprot ID#P19224) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.56 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153231 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, H1299, mouse liver.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules such as steroids, bilirubin, hormones, and drugs into water-soluble metabolites.
This gene is part of a complex locus encoding several UDP-glucuronosyltransferases, including thirteen unique alternate first exons followed by four common exons.
Four of these alternate first exons are pseudogenes, while the remaining nine can be spliced to the common exons, producing proteins with distinct N-termini and identical C-termini.
Each first exon encodes the substrate binding site and is regulated by its own promoter.
The enzyme is active on phenolic and planar compounds. Alternative splicing in the 5′ region results in two transcript variants.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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