Thermo Fisher Scientific NEDD4L Polyclonal Antibody
Western blot과 Immunoprecipitation에 적합한 Rabbit Polyclonal Antibody. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. 4°C에서 보관하며 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 225 and 275 of human neural precursor cell expressed, developmentally down-regulated 4-like |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
NEDD4L is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 enzyme to target substrates. It inhibits TGF-beta signaling by promoting SMAD2 and TGFR1 ubiquitination and degradation. NEDD4L also mediates ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav, Kv, EAAT1, and CLC5, and promotes degradation of SGK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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