Thermo Fisher Scientific Phospho-CDK4 (Thr172) Recombinant Superclonal Antibody (9HCLC)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with Monkey, Pig, and Horse.
• Recombinant rabbit Superclonal™ antibodies are composed of multiple recombinant monoclonal antibodies, combining polyclonal sensitivity with monoclonal specificity.
• Each lot maintains consistent composition, eliminating variability typical of polyclonal antibody production.
• Formerly called “Recombinant Polyclonal Antibody”, now rebranded as “Recombinant Superclonal™ Antibody”.
• Physical product and performance remain unchanged.

Target Information

CDK4/cyclin D3 serine/threonine kinase is a dimeric complex involved in controlling cell proliferation during the G1 phase of the cell cycle.
CDK4 forms a complex with D-type cyclins and is inhibited by p16. It mediates phosphorylation of the C-terminal region of Rb protein, leading to transcriptional repression of the E2F complex.
CDC37 and HSP90 associate with CDK4 not bound to D-type cyclins.
SMAD3 is a major substrate of CDK4 and CDK2.
CDK6 and CDK4 phosphorylate Rb protein at different residues (CDK6: Thr821, CDK4: Thr826).

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.