Thermo Fisher Scientific Phospho-A-Raf (Ser299) Polyclonal Antibody
인간 A-Raf의 Ser299 인산화 부위에 특이적인 Rabbit Polyclonal Antibody. IHC(Paraffin)에서 1:50–1:100 희석으로 사용 가능. 액상 형태로 1 mg/mL 농도, -20°C 보관. 신호전달 경로 연구용으로 적합.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human A-RAF around the phosphorylation site of Ser299 (R-D-SP-G-Y) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556279 |
Target Information
Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk), and Raf-1.
Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity, broadly expressed in nearly all cell lines tested to date. It is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus.
The unregulated kinase activity of v-Raf has been associated with transformation and mitogenesis, while Raf-1 activity is normally suppressed by a regulatory N-terminal domain.
A-Raf, another member of the Raf gene family, shows substantial homology to Raf-1 within the kinase domain but less elsewhere. Expression of A-Raf is highest in urogenital tissues and kidney, and lowest in brain tissue.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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